Genetic Alterations in Medullary Thyroid Cancer: Diagnostic and Prognostic Markers
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چکیده
منابع مشابه
Genetic Alterations in Medullary Thyroid Cancer: Diagnostic and Prognostic Markers
Medullary thyroid carcinoma (MTC) is a rare calcitonin producing neuroendocrine tumour that originates from the parafollicular C-cells of the thyroid gland. The RET proto-oncogene encodes the RET receptor tyrosine kinase, with consequently essential roles in cell survival, differentiation and proliferation. Somatic or germline mutations of the RET gene play an important role in this neoplasm in...
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Medullary thyroid carcinoma (MTC) is an infrequent calcitonin-producing neuroendocrine tumor that initiates from the parafollicular C cells of the thyroid gland. Several genetic and epigenetic alterations are collaterally responsible for medullary thyroid carcinogenesis. In this review article, we shed light on all the genetic and epigenetic hallmarks of MTC. From the genetic perspective, RET, ...
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The MAPK/ERK (mitogen-activated protein kinase/extracellular signal- regulated kinase signaling pathway) and PI3K/Akt (lipid kinase phoshoinositide-3-kinase signaling pathway) play an important role in transmission of cell signals through transduction systems as ligands, transmembrane receptors and cytoplasmic secondary messengers to cell nucleus, where they influence the expression of genes th...
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Thyroid cancer is a malignancy of the thyroid parenchymal cells. There are four main types of thyroid cancer: papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), anaplastic thyroid carcinoma (ATC), and Medullary thyroid carcinoma (MTC). Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor of the thyroid gland derived from parafollicular C-cells that produce calcitonin (CT...
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Bladder cancer has the highest recurrence rate of any solid tumor. Due to the need for lifelong surveillance, the per-patient cost of managing bladder cancer is among the highest for any cancer. There has been growing activity in the development of novel markers for bladder cancer detection; the ultimate goal of these novel markers would be to replace and/or complement cystoscopy as a sensitive...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2011
ISSN: 1389-2029
DOI: 10.2174/138920211798120835